Is there any new research on disagreements between Dr Longo and Dr Sinclair? I do appreciate both of them, but I would like to be able to decide on their contradictory claims, specifically:
Personally I think Longo miss represents some of the data.
He bases a lot of his information on blue zones and concludes that they consume roughly 30% of their daily calories from animal products such as dairy, meat, fish.
Then also talks about their legume consumption being very high.
This isn’t a low protein diet by any means. Actually quite the contrary.
As a side note. Any benefits from fasting such as autophagy is also seen in periods calorie restriction (dieting). So fasting isn’t necessary.Also there is plenty of studies showing the benefit of spacing out your meals to improve hypertrophy(muscle building) and that strength is one of the biggest predictors of life expectancy.
Depends on the eater’s goals, there’s no such thing as a one sized fits all optimal way to eat without knowing what someone is trying to accomplish.
For example, do you think Longo’s advice is good for people who frequently lift weights? ofc not.
>Is skipping breakfast good or bad - Longo advises having breakfast, and Sinclair recommends OMAD.
I don’t think we really know the answer to this. So in mouse studies OMAD seems to do better. But in observational studies people who eat breakfast have better health outcomes.
I personally am not usually that hungry in the morning so skip breakfast. It’s probably an individual thing, but I think a one or two meals a day is better than three.
There are soo many factors at play it’s hard to say one is better than another.
One thing I do notice is that Sinclair doesn’t have normal/healthy biology or habits. So what he does isn’t really applicable. So he doesn’t exercise as much as you should, hence he can work in metformin into his routine. If you are trying to exercise as much as you should then the interference effect from metformin could be an issue.
If you are hitting the gym in the morning, then maybe breakfast is a good idea. I personally use exercise in the morning and consume EAA, so I can skip breakfast.
>The amount of proteins - low (Longo) vs moderately high (Sinclair)
From the lower mechanistic view, lower protein consumption seems like it be associated with longevity. But we also know that muscle strength is highly correlated with longevity in studies in humans, which suggests high intake might be better.
I personally would never change what I do solely based on what Sinclair says.