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Heard the advice of "Eat every 4-5 hour to avoid Ghrelin spike", how does this factor into IF?

Heard in a Kiana Docherty video

Answer

Just because ghrelin spikes doesn’t mean you have to respond by eating? It’s secreted to help regulate blood glucose levels in addition to insulin. I think it also stimulates growth hormone.

There are many pathways to regulating your body’s functions. It is perfectly capable of surviving for more than 5 hours without food. Do you wake up in the middle of the night to eat to address ghrelin spikes?