This is a question for your doctor honestly. I also have meds I need to take twice a day. Some meds need to be taken with food to avoid nausea. Others actually work better with food. In my case I talked to my doctor and she said it’s ok to take it with my first and last meal (i also do 8:16). So now I i focus less on doing the full 16h but rather focus on getting at least 8h between the 2 meals so that it don’t accidentally take the doses even closer together.
But what is ok or not ok to do with your specific meds should be a chat with your doctor or at least pharmacist.