Carbs could be one of the issues and the blood sugar/insulin spike.
If I do OMAD and it is heavy on carbs (personally for me “heavy” means around and above 50% of my meal) I feel sluggish too and also heavy afterwards for hours.
Also the food coma effect doesn’t work with my schedule so I try to avoid OMAD.Instead I’m doing 18/6 and alternating days of fasting.
That way on the day when I do 18/6 I don’t get an insulin spike by splitting my calories into 2 meals (2MAD) and I catch up on extended fasting state the next day.
Are you only eating 800 calories for your meal? How much fat are you eating? I wasn’t getting nauseous but I was feeling weak after about week three until I started eating more. I was eating around 1500-1700 calories in my meal. I stepped that up to around 2000-2200 and started feeling better. It did not effect weight loss either.