I think the protocol that you can stick with for the long term is the best one for you.Personally, I started with 16/8, ramped up as high as rolling 46s, but decided 23.5/.5 is the most sustainable for me, so have been doing that for a while now.
The absolute best benefit you can get through fasting is a reassessment of your relationship with food. It would be harder for you to have that epiphany if you are focusing all your energy in struggling to get through an arduous long fast. This is how the absolutely best fasting protocol (if there were such a thing) would not be the one best suited for you.
Personal story time! It used to be that I could not be hungry at any time; if I was hungry it was time to eat. It also used to be that I was seriously hooked on snacking; most afternoons at work I would have two or three so called healthy snacks that were just to kill boredom and to take mental breaks. After my fasts I got to see my demons naked and they were really not that hard to deal with at all. My snacking is gone. My impulse to eat when I was hungry is under control. My impulse eating in general is under control. All because after a few fasts I could see that all my hunger was not even a physical thing but emotional eating.
So; you want to lose a bunch of weight? Fasting is probably the fastest and easiest way to accomplish that but more importantly to help you fix your diet. Start fasting and simply look at the timing that best work for you and your lifestyle. if you get to OMAD give a 4 day fast a try; there is no point of doing 2 days for your first long fast, by then your appetite should be properly closed and may as well do 4.