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Should B6 dosage be increased when taking amounts of B12?

Would b12 cause any depletion of b6, if using high amounts of b12 (eg 500mcg)

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Answer

Hello,

The attached articles don’t list B12 as depleting any particular minerals, although there can be some drug interactions. In short, it doesn’t appear that high amounts of b12 would require extra B6.

https://lpi.oregonstate.edu/mic/vitamins/vitamin-B12#safety

https://ods.od.nih.gov/factsheets/VitaminB12-HealthProfessional/#h8

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