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Why did pregnenolone cure my Delayed Sleep Phase Disorder (DSPD)?

DSPD has been the bane of my existence. Not being able to wake up before noon affected my academic, career, and social life. I tried everything for years and it was only after supplementing pregnenolone, which I read had nootropic effects, that I noticed the side effect of waking up earlier and going to bed earlier.

What physiological reaction is happening?

One interesting thing is that all the benefits pregnenolone disappeared when I took up smoking and then immediately came back when I stopped. Is nicotine an antagonist?

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Answer

I’m not an expert. But there are studies showing pregnenolone does effect sleep in a positive way. Here’s one for example:

https://www.sciencedirect.com/science/article/abs/pii/000689939390037N

They weren’t able to specify how it worked, but it effected GABA-A receptors.

There’s probably more studies out there that look more indepth into it if you’re willing to look.

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