DSPD has been the bane of my existence. Not being able to wake up before noon affected my academic, career, and social life. I tried everything for years and it was only after supplementing pregnenolone, which I read had nootropic effects, that I noticed the side effect of waking up earlier and going to bed earlier.
What physiological reaction is happening?
One interesting thing is that all the benefits pregnenolone disappeared when I took up smoking and then immediately came back when I stopped. Is nicotine an antagonist?
I’m not an expert. But there are studies showing pregnenolone does effect sleep in a positive way. Here’s one for example:
https://www.sciencedirect.com/science/article/abs/pii/000689939390037N
They weren’t able to specify how it worked, but it effected GABA-A receptors.
There’s probably more studies out there that look more indepth into it if you’re willing to look.