> 14 individuals with rheumatoid arthritis (RA) participated in a 1 week fast, with inflammatory marker measurements taken before and after the fast. They found that fasting reduced the release of leukotriene B4 from RA neutrophils, reduced the generation of cytotoxins from serum and altered the phospholipid fatty acid composition.
> It was shown that the phospholipid composition changed following the fast with a resulting reduction of LTB4 production, demonstrating an anti-inflammatory effect of fasting.
So I see that a week of fasting can reduce LTB4, does anyone know the least amount of time where we can achieve that. I do OMAD and curious if it kicks in for shorter amounts of time but can’t really find it anywhere. Really trying to kick my inflamed sinuses and might have to go for longer fasts, I’m a type 1 diabetic so trying to avoid it but if I can achieve the same through shorter fasts that would be great. I just don’t see any science on short time-frames fasts or even with mice, so curious if others know the science.
Hi, I think it depends on the level of sickness. In my case, it took 2 months of caloric restriction (500 calories less per day- I ate around 1300) which slowly decreased my inflammation, then 48 hours of full fasting (just water) which got me to an amazing level, I thought of continuing to 72 hours as I felt it would be leaving even better (you notice if you are still inflamed a bit) and then I have a 24 full maintenance each week when not exercising and fasted walks when exercising. It has been a long way to get me to this state. You should try a combination of these things, even ketogenic diet (I tried once in a while when I do not want to lose weight). But overall fasting is amazing to relieve inflammation. The watchout is that it will come back unless you maintain the level you achieved via exercise or caloric restriction. I negated the fact that I could never eat normal again, I always went back to eating a lot after fasting and suddenly I was again in the same situation. I need to eat smaller meals and healthy food al the time! And if somehow I screw up with food, then I fast the next day to get to the level I was. Hope my experience helps!